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[目的]探讨直肠癌患者中尾型同源盒基因-2(CDX2)蛋白检测的临床意义。[方法]采用Western blot检测50例直肠癌组织及癌旁组织CDX2蛋白的表达,以20例正常直肠组织作为对照组。[结果]CDX2蛋白在癌组织中表达低于癌旁组织,且癌旁组织中表达低于对照组,差异均有统计学意义(P<0.01);CDX2蛋白在直肠癌组织中的表达与Dukes分期、组织分化、淋巴结转移和3年生存率有关,而与患者性别、年龄、肿瘤的部位及病理组织学类型无关。[结论]CDX2蛋白的表达情况可作为评估直肠癌肿瘤恶性程度、临床分期、侵袭转移及预后的参考指标。
[Objective] To investigate the clinical significance of detection of CDX2 protein in patients with rectal cancer. [Method] The expression of CDX2 protein in 50 cases of rectal cancer tissues and adjacent tissues was detected by Western blot. Twenty normal rectal tissues were used as the control group. [Results] The expression of CDX2 protein in cancerous tissue was lower than that in paracancerous tissue, while the expression in paracancerous tissue was lower than that in control group (P <0.01). The expression of CDX2 protein in colorectal carcinoma was significantly correlated with Dukes Staging, tissue differentiation, lymph node metastasis and 3-year survival rate, but not with the patient’s gender, age, tumor location and histopathological types. [Conclusion] The expression of CDX2 protein can be used as a reference index to evaluate the malignant degree, clinical stage, invasion, metastasis and prognosis of rectal cancer.