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胆道系统恶性肿瘤发病率不高,总体预后差。手术、化疗、放疗等治疗手段效果均不佳。近年来,人们对胆道系统恶性肿瘤分子机制逐步深入了解,确立了一些新的关键性基因和信号通路改变,认识到不同来源胆道系统恶性肿瘤的发生发展分子机制存在明显不同,从而为其向药物个体化治疗确定了新方向。本文就相关内容进行综述。1胆道系统恶性肿瘤常见的基因和信号通路改变近年来,随着二代测序等分子检测技术的日趋完善,一
The incidence of malignant biliary tract cancer is not high, the overall prognosis is poor. Surgery, chemotherapy, radiotherapy and other treatment methods are not good. In recent years, people gradually understand the molecular mechanism of malignant tumors of the biliary system, established a number of new key genes and signal pathways to change, recognizing the different sources of biliary system malignant tumor occurrence and development of molecular mechanisms exist significantly different, so as to the drug Individualized treatment has set a new direction. This article summarizes the relevant content. A common biliary system malignant tumor genes and signal changes in recent years, with second-generation sequencing and other molecular detection techniques are maturing, a