A complicated Cu-Ni based alloy was developed to fabricate wear-resisting bush for high temperature application. The concern focuses on the control of equiaxed grains in the developed alloy ingot prepared by centrifugal casting. The results show that the equiaxed grains are determined by the pouring temperature of the melt, the cooling rate and the rotation speed of the mold. With the decrease in pouring temperature, the fraction of the equiaxed grains in the transverse section of the ingot increases and the average length of columnar grain decreases. When the pouring temperature is confined below 1,2500C,complete equiaxed grains can be obtained.Based on the optimal centrifugal casting processing, the tensile strength of the developed alloy ingot with complete equiaxed grains reaches to 810 MPa and 435 MPa at room temperature and 5000C,respectively, which is 14% and 110% higher than that of common commercial QAI10-4-4 alloy. The wear rate of the developed alloy times lower than that of QAI10-4-4 alloy.