【摘 要】
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目的 探讨羟基红花黄色素A对6-OHDA诱导的帕金森病小鼠模型的神经保护作用及机制.方法 通过旋转实验检测羟基红花黄色素A对6-OHDA诱导的帕金森病小鼠模型的神经保护作用;末次
【机 构】
：
272029,山东省济宁医学院附属医院神经内科
论文部分内容阅读
目的 探讨羟基红花黄色素A对6-OHDA诱导的帕金森病小鼠模型的神经保护作用及机制.方法 通过旋转实验检测羟基红花黄色素A对6-OHDA诱导的帕金森病小鼠模型的神经保护作用;末次行为学试验后取脑,采用高效液相色谱-荧光检测法测定5-羟色胺(5-HT)水平;采用试剂盒测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮合酶(NOS)水平.结果 与空白组比较,对照组的旋转圈数明显增加(P<0.05),实验组的爬杆时间明显缩短(P<0.05);使用羟基红花黄色素A治疗后实验组的旋转圈数明显降低(P<0.05);羟基红花黄色素A能明显提高细胞中5HT、SOD、GSH-Px的水平,降低NOS的水平,提高抗氧化能力.结论 羟基红花黄色素A对6-OHDA诱导的帕金森病小鼠模型具有神经保护作用,其机制可能与抗氧化作用有关.
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