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目的了解口腔鳞癌(OSCC)组织中基质金属蛋白酶-2(MMP-2)的表达情况,探讨其与OSCC组织浸润转移潜能及预后的关系。方法采用免疫组化SP法检测30例口腔鳞癌组织和10例正常口腔黏膜组织中MMP-2的表达,分析其表达与临床指标的关系。结果 OSCC中MMP-2的表达显著高于正常口腔黏膜组(P<0.05),其阳性表达率分别为76.7%和10%,深层浸润的口腔鳞癌组织中,MMP-2的阳性表达率显著高于浅层浸润的口腔鳞癌组织(P<0.05)。结论 OSCC中MMP-2的表达显著高于正常口腔黏膜组织,MMP-2的阳性表达与肿瘤浸润程度密切相关。
Objective To investigate the expression of matrix metalloproteinase-2 (MMP-2) in oral squamous cell carcinoma (OSCC) and to explore the relationship between the expression of MMP-2 and the invasive and metastatic potential and prognosis of OSCC. Methods Immunohistochemical SP method was used to detect the expression of MMP-2 in 30 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa. The relationship between the expression of MMP-2 and clinicopathological parameters was analyzed. Results The positive expression rate of MMP-2 in OSCC was significantly higher than that in normal oral mucosa (P <0.05), and the positive rate was 76.7% and 10%, respectively. The positive expression rate of MMP-2 in OSCC was significantly higher than that in normal oral mucosa Higher than the shallow infiltration of oral squamous cell carcinoma (P <0.05). Conclusion The expression of MMP-2 in OSCC is significantly higher than that in normal oral mucosa. The positive expression of MMP-2 is closely related to the degree of tumor invasion.