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以猪油酸型急性肺损伤模型为实验对象，观察急性发病过程中心肺功能和肺实质的病理改变。结果表明：急性肺损伤对肺功能影响主要为肺静态顺应性、氧合指数、血氧分压和pH下降。气道峰压、吸气未平台压、气道阻力明显升高。分流量明显加大。血液动力学上表现为心输出量，氧运输下降，平均肺动脉压、肺血管阻力和全身血管阻力显著升高；右心房压、肺毛细血管模压和体循环动脉压基本不变；病理形态表现为典型的急性肺损伤。结果显示，本实验成功制成急性防损伤模型，并有显著的心肺功能不良改变。
LPS-induced acute lung injury model was used as the experimental object to observe the changes of cardiopulmonary function and pulmonary parenchyma during acute onset. The results showed that the main effects of acute lung injury on pulmonary function were pulmonary static compliance, oxygenation index, partial pressure of oxygen and pH. Peak airway pressure, inspiratory platform pressure, airway resistance was significantly increased. Sub-flow significantly increased. Hemodynamics showed cardiac output, oxygen transport decreased, mean pulmonary arterial pressure, pulmonary vascular resistance and systemic vascular resistance increased significantly; right atrial pressure, pulmonary capillary compression and systemic arterial pressure remained unchanged; typical pathological manifestations Acute lung injury. The results show that the experiment successfully made acute injury model, and significant changes in cardiopulmonary dysfunction.