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目的:对比法莫替丁三联二周疗法(法莫替丁、阿莫西林、甲硝唑)和德诺三联疗法(德诺、、阿莫西林、甲硝唑)对确诊幽门螺杆菌(Hp)阳性十二指肠溃疡(Du)的疗效。方法:将84例病例随机分为两组即法莫替丁组和德诺组,内镜和活检组织检查在服药前及停药后4周进行。结果:法莫替丁组溃疡愈合率76.2%,Hp根除率71.4%,德诺组溃疡愈合率80.9%,Hp根除率73.87%,两组比较,差异无统计学意义。结论:两种方案均获得良好疗效,但A组方案费用低,不良反应少,患者依从性好,值得在经济欠发达地区推广应用。
OBJECTIVE: To compare the efficacy and safety of famotidine triple therapy (famotidine, amoxicillin, metronidazole) and de novo triple therapy (de novo, amoxicillin and metronidazole) in the diagnosis of Helicobacter pylori (Hp ) Positive duodenal ulcer (Du) effect. Methods: Eighty - four cases were randomly divided into two groups: famotidine group and dexeo group. Endoscopy and biopsy were performed before and after treatment for 4 weeks. Results: The healing rate of ulcer in famotidine group was 76.2%, Hp eradication rate was 71.4%, Denon group ulcer healing rate was 80.9% and Hp eradication rate was 73.87%. There was no significant difference between the two groups. Conclusion: Both of the two regimens have achieved good curative effect. However, the cost of the regimen in group A is low, the adverse reactions are few, and the patient compliance is good. It is worth to popularize and apply in the economically underdeveloped areas.