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Ⅰ.麻风菌对小鼠足垫的感染力作为疗效判断指标瘤型(LL)麻风短程化学治疗试验的目的是确定药物或治疗方案的效果,所用疗效判断指标应当仅反映治疗本身的作用,故需除去和控制影响试验结果的各种治疗前或治疗中变数的作用。部分治疗研究应用活检标本中麻风菌对小鼠足垫感染力丧失的速度作为疗效判断指标。只有在感染力丧失速度不受其它因素明显影响下,该指标才有价值。以往治疗试验仅涉及少量病人,无法探讨患者的各种特点(即变数)对该指标的影响。近年,美国麻风研究委员会与伍德基金会协作先后组织二批治疗研究,试验
I. Infectivity of Leprosy on Foot Pad of Mice as Indicators of Efficacy The purpose of the LL test of short-range chemotherapy for leprosy is to determine the effect of the drug or treatment regimen, and the indicators of efficacy used should only reflect the effect of the treatment itself The effects of various pre-treatment or treatment-dependent variables that affect the test result need to be removed and controlled. Part of the treatment of biopsy specimens used in leprosy specimens of mouse footpad infectivity loss rate as a curative effect indicators. This indicator is of value only if the rate of contagion is not significantly affected by other factors. Previous treatment trials involving only a small number of patients, can not explore the characteristics of patients (variables) on the impact of the index. In recent years, the Leprosy Research Committee of the United States and the Wood Foundation have organized two batches of treatment research and experiments