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为探讨大气总悬浮颗粒物的肺毒性和抗毒性物质，采用支气管直接注入染毒的方式和食物强化ＶＡ、ＶＥ、ＶＣ、Ｚｎ和Ｓｅ的方法进行实验研究，结果表明染毒后大鼠脏体比发生变化，肺体比、肝体比和脾体比阳性对照组高于阴性对照组和各强化组并具有统计学意义，而各强化组与阴性组相比差别无显著性。同样大鼠肺灌洗液中ＬＤＨ、ＡＣＰ和ＮＡ的变化也显示阳性组高于阴性对照组和各强化组，而各强化组与阴性对照组相比差别无显著性。肺组织匀浆中ＬＰＯ、ＧＳＨ－Ｐｘ测定结果表明阳性组ＬＰＯ增高、ＧＳＨ－Ｐｘ下降，各强化组变化不明显。说明大气颗粒物可诱发体内产生脂质过氧化并引起肺部损伤，ＶＡ、ＶＥ、ＶＣ、Ｚｎ和Ｓｅ具有减轻大气颗粒物致肺部的损伤作用。
In order to investigate the pulmonary toxicity and anti-toxicity substances of total suspended particulates in the atmosphere, the methods of direct injection of bronchial injections and food fortification of VA, VE, VC, Zn and Se were used to study the results. The ratio of pulmonary body, liver body and spleen was higher than that of negative control group and each intensive group, but there was no significant difference between each intensive group and negative group. Similarly, changes of LDH, ACP and NA in rat lung lavage also showed that the positive group was higher than the negative control group and each intensive group, while the difference between the intensive group and the negative control group was not significant. LPO and GSH-Px in lung tissue homogenate showed that LPO increased and GSH-Px decreased in the positive group, while the changes in each intensive group were not obvious. It is concluded that atmospheric particulate matter can induce lipid peroxidation in vivo and lead to lung injury. VA, VE, VC, Zn and Se can alleviate the damage of airborne particles to the lungs.