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目的:分析鲑鱼降钙素鼻喷剂对维持性血液透析患者骨密度的影响。方法:选取2010年11月—2014年10月肾内科收治的实施维持性血液透析患者40例,将其分为治疗组和对照组,每组20例;在血液透析时,治疗组患者均给予鲑鱼降钙素鼻喷剂治疗,对照组患者均给予常规钙剂和骨化三醇疗效,观察记录患者治疗前和治疗半年后患者腰椎骨密度情况和髋部骨密度情况;并测定和分析患者骨代谢生化标志物的变化情况。结果:治疗组患者第2腰椎以及腰椎总体Z值,第3腰椎以及腰椎总体t值优于对照组(P<0.05);治疗组患者股骨大转子、粗隆间、髋部骨密度总体Z值和t值均优于对照组(P<0.05);治疗半年后,治疗组维持性血液透析患者,其骨代谢生化指标中血N-MID、PINP、β-Crosslaps、PTH的测定结果与对照组比较其差异无统计学意义(P>0.05)。结论:鲑鱼降钙素鼻喷剂用于治疗维持性血液透析患者,能够有效改善患者的骨密度,安全可靠,其疗效优于常规钙剂和骨化三醇治疗。
OBJECTIVE: To analyze the effect of salmon calcitonin nasal spray on bone mineral density in maintenance hemodialysis patients. Methods: Forty patients with maintenance hemodialysis who were admitted to Department of Nephrology between November 2010 and October 2014 were divided into treatment group and control group, with 20 cases in each group. In hemodialysis group, patients in treatment group were given Salmon calcitonin nasal spray treatment, the control group patients were given conventional calcium and calcitriol efficacy observed and recorded in patients with pre-treatment and six months after treatment of patients with lumbar spine bone mineral density and hip density; and determination and analysis of patients Changes in biochemical markers of bone metabolism. Results: The second lumbar vertebra of the treatment group and the total Z value of the lumbar spine, the third lumbar vertebra and the lumbar spine were better than the control group (P <0.05). The total Z value of the femoral trochanter, intertrochanteric and hip bone mass in the treatment group (P <0.05). After six months treatment, the serum levels of N-MID, PINP, β-Crosslaps and PTH in the patients with maintenance hemodialysis in the treatment group were significantly higher than those in the control group The difference was not statistically significant (P> 0.05). CONCLUSIONS: Salmon calcitonin nasal spray is a safe and effective treatment for maintenance hemodialysis patients, which is superior to conventional calcium and calcitriol treatment.