目的探讨具有多囊卵巢综合征(PCOS)表型的绝经女性心血管疾病的发生风险。方法以2005-01-01—2007-12-31于苏州大学附属第二医院健康体检的绝经女性346例为研究对象,根据有无PCOS表型分为2组:PCOS表型组(57例)和非PCOS表型组(289例)。随访以电话随访为主,辅以住院随访、门诊随访等。随访间歇为3个月,随访终点为主要不良心血管事件(MACE),随访截止日期为2014-12-31。生存率估算应用Kaplan-Meier法,组间生存率曲线差异采用log-rank检验,应用多变量Cox比例风险回归分析MACE的独立危险因素。结果非PCOS表型组有10例出现MACE,PCOS表型组有7例出现MACE。Kaplan-Meier曲线显示PCOS表型组无MACE生存率显著下降(χ2=4.754,P=0.023)。多变量Cox比例风险回归分析发现高密度脂蛋白胆固醇(HDL-C)较低、超敏C反应蛋白(hsCRP)较高和存在PCOS表型是MACE的独立预测因素。结论 PCOS表型是绝经女性发生心血管疾病的独立危险因素,有助于进一步行危险分层,且提示PCOS与心血管疾病密切相关。 Objective To investigate the risk of cardiovascular events in postmenopausal women with polycystic ovary syndrome (PCOS) phenotype. Methods A total of 346 cases of postmenopausal women who underwent physical examination in the Second Affiliated Hospital of Soochow University from January 2005 to January 2007 were enrolled in this study. The PCOS phenotypes were divided into two groups according to the presence or absence of PCOS phenotype: 57 cases And non-PCOS phenotype (289 cases). Follow-up by telephone follow-up, supplemented by hospital follow-up, out-patient follow-up. The follow-up interval was 3 months. The end point of follow-up was MACE. The deadline for follow-up was 2014-12-31. The Kaplan-Meier method was used to estimate the survival rate. Log-rank test was used to evaluate the difference of survival rate between groups. Multivariate Cox proportional hazards regression was used to analyze the independent risk factors of MACE. Results MACE was found in 10 cases in non-PCOS phenotype group and 7 cases in PCOS phenotype group. Kaplan-Meier curves showed no significant decrease in MACE survival in PCOS phenotypes (χ2 = 4.754, P = 0.023). Multivariate Cox proportional hazards regression analysis found that low HDL-C, high hsCRP and PCOS phenotype were independent predictors of MACE. Conclusions PCOS phenotype is an independent risk factor for cardiovascular disease in postmenopausal women and is helpful for further risk stratification. It also suggests that PCOS is closely related to cardiovascular disease.