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目的研究胃癌患者的舌苔变化与血清表皮生长因子(EGF)水平及临床实验室指标的关系。方法通过检测266例胃癌患者(胃癌组)和246例正常对照人群(对照组)血清EGF水平,记录舌象表现及实验室检测结果(包括白细胞计数、中性粒细胞、淋巴细胞、单核细胞、总蛋白、门冬氨酸氨基转移酶、血糖),分析舌苔、血清EGF水平及实验室指标的关系。结果胃癌组厚苔比例最高(51.5%),而对照组薄苔比例最高(64.6%)。胃癌组白细胞计数、淋巴细胞、总蛋白异常者,其薄苔比例下降,厚苔比例增高(P<0.01)。胃癌组血清EGF水平比对照组明显升高(P<0.01)。胃癌组和对照组总蛋白降低时血清EGF均明显高于正常者(P<0.01);相关分析表明,两组受试者总蛋白与血清EGF水平均呈负相关(P<0.01)。结论白细胞、淋巴细胞、总蛋白等临床检验的异常与胃癌患者舌苔薄厚及血清EGF水平具有密切关系。
Objective To study the relationship between changes of tongue coating in patients with gastric cancer and serum epidermal growth factor (EGF) and clinical laboratory parameters. Methods The levels of serum EGF were measured in 266 patients with gastric cancer (gastric cancer group) and 246 healthy controls (control group). The tongue performance and laboratory test results (including white blood cell count, neutrophils, lymphocytes, monocytes , Total protein, aspartate aminotransferase, blood glucose), analysis of tongue coating, serum EGF levels and laboratory parameters. Results The proportion of thick moss in gastric cancer group was the highest (51.5%), while that in the control group was the highest (64.6%). Gastric cancer group, white blood cell count, lymphocytes, total protein abnormalities, the proportion of thin moss decreased, the proportion of thick moss increased (P <0.01). The level of serum EGF in gastric cancer group was significantly higher than that in control group (P <0.01). The serum EGF levels of gastric cancer group and control group decreased significantly (P <0.01). Correlation analysis showed that there was a negative correlation between total protein and serum EGF level in gastric cancer group and control group (P <0.01). Conclusions The abnormalities of clinical tests such as white blood cells, lymphocytes and total proteins are closely related to the thickness of the tongue fur and the level of serum EGF in patients with gastric cancer.