β-受体阻断药在心血管病的治疗中占有相当重要的地位,对缺血性心脏病有肯定的疗效。但也存有不良反应或禁忌症,其中有的是由于其选择性不高所致。因此,寻找特异性的β_1受体阻断药是目前研究抗心肌缺血药的一个重要方面。据报道,在β-受体阻断药的基本有效结构的苯环的对位与4(3H)-喹唑酮环的2位 β-blockers in the treatment of cardiovascular disease occupy a very important position, have a positive effect on ischemic heart disease. However, there are also adverse reactions or contraindications, some of which are due to its low selectivity. Therefore, looking for specific β 1 receptor blocker is currently an important aspect of the study of anti-ischemic drugs. It has been reported that the para position of the benzene ring, which is the basic structure of the beta-blocker, and the 2 position of the 4 (3H) -quinazolone ring