论文部分内容阅读
目的分析650例不同孕期妇女的甲状腺功能指标检测结果,了解妊娠早、中、晚期上述指标的变化规律及相关性。方法选择在嘉兴市妇幼保健院建册并定期孕检的275例孕早期、193例孕中期及182例孕晚期健康妇女作为研究对象。检测孕妇血清中促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT_3)、游离三碘甲状腺原氨酸(FT_3)、总四碘甲状腺原氨酸(TT_4)、游离四碘甲状腺原氨酸(FT_4)的水平。分析各指标在孕早、孕中及孕晚期的变化规律及相互间的相关性。结果 TSH、FT_3、FT_4是评价甲状腺功能的主要指标,TSH与FT_3、FT_4处于一种促进和抑制的依赖关系,TSH血清水平随孕周增加逐渐升高,FT_3、FT_4、TT_3则逐渐下降。结论妊娠早、中、晚特异性甲状腺功能参数可准确评价妊娠期甲状腺功能,对降低妊娠并发症发生率,改善妊娠结局,提高儿童的智力水平具有积极的临床意义。
Objective To analyze the detection results of thyroid function in 650 pregnant women of different stages of pregnancy to understand the changes and correlations of these indexes in early, middle and late stages of pregnancy. Methods 275 pregnant women, 193 pregnant women and 182 pregnant women of the third trimester were enrolled in Jiaxing MCH and regular pregnancy test. Serum levels of thyroid stimulating hormone (TSH), total triiodothyronine (TT_3), free triiodothyronine (FT_3), total tetraiodothyronine (TT_4), free tetraiodothyronine Acid (FT_4) level. The changes of each index in the first trimester of pregnancy, the second trimester of pregnancy and the third trimester of pregnancy were analyzed. Results TSH, FT_3 and FT_4 were the main indexes to evaluate thyroid function. TSH and FT_3 and FT_4 were in a promotion and inhibition dependent manner. TSH serum level increased gradually with the increase of gestational age, while FT_3, FT_4 and TT_3 decreased gradually. Conclusion The specific thyroid function parameters of early, middle and late pregnancy can accurately evaluate thyroid function in pregnancy, which has a positive clinical significance for reducing the incidence of pregnancy complications, improving the pregnancy outcome and increasing the intelligence level in children.