1,25-二羟维生素D3(1,25(OH)2D3)是维生素D3经肝、肾代谢后的主要活性形式,有着重要的生理生化活性[1]。研究发现,1,25(OH)2D3不仅参与钙、磷代谢与骨质钙化,还参与调节细胞的生长分化等过程,其对机体的非钙调效应十分广泛,最重要的是调节免疫、诱导肿瘤细胞分化、抑制肿瘤细胞 1,25-dihydroxyvitamin D3 (1,25 (OH) 2D3) is the main active form of vitamin D3 after liver and kidney metabolism and has important physiological and biochemical activities [1]. The study found that 1,25 (OH) 2D3 not only involved in calcium and phosphorus metabolism and bone calcification, but also involved in the regulation of cell growth and differentiation process, its non-calcium on the body effect is very wide, the most important is the regulation of immunity, induction Tumor cell differentiation, inhibition of tumor cells