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关于链檄素、对氨柳酸钠、氨硫脲、异烟肼对于结核病的疗效,根据近年来,我国、苏联及其它国家的临床经验证明:链檄素对粟粒结核、亚急性血行播散性肺结核、结核性脑膜炎、上呼吸道结核性溃疡及其它新鲜的浸润性病变有显著效果。对慢性纤维性病变、干酪性病变无效。且使用时间长久或用量不当,可有第八神经扰乱现象;如头晕、耳鸣、重听;或引起发热、皮疹、紫斑等过敏反应;此外,有时产生抗药性。因此,在使用键霉素时,除疗程不可太长,以避免发生反应外,还应与对氨柳酸钠、异烟肼合并使用,以减少或延缓抗药性的产生。对氨柳酸钠对肠结核、肾结核疗效显著。对有全身中毒症状的结核病患者有解毒功效。与链霉素、异烟肼等药品合并使用时,可起协同作用。其缺点为需长期使用,且常常引起恶心、呕吐食欲减退等胃肠症状。故此药每与其他药品合并使用,单独使用者较少。
On the chain of cantharidin, the sodium salicylate, thiosemicarbazide, isoniazid for the treatment of tuberculosis, according to recent years, China, the Soviet Union and other countries have shown that clinical experience: chalazion on miliary tuberculosis, subacute hematogenous spread Tuberculosis, tuberculous meningitis, upper respiratory tract tuberculous ulcers and other fresh infiltrative lesions have a significant effect. Chronic fibrosis, cheese disease invalid. And the use of long-term or inappropriate dosage may have the eighth nerve disturbances; such as dizziness, tinnitus, re-hearing; or cause fever, rash, purple spots and other allergic reactions; In addition, sometimes drug resistance. Therefore, the use of amikacin, in addition to treatment should not be too long to avoid the reaction, but also should be combined with sodium salicylate, isoniazid to reduce or delay the emergence of drug resistance. Sodium salicylate on intestinal tuberculosis, renal tuberculosis significant effect. Detoxification of tuberculosis patients with symptoms of systemic poisoning. With streptomycin, isoniazid and other drugs used in combination, can play a synergistic effect. The disadvantage is the need for long-term use, and often cause nausea, vomiting, loss of appetite and other gastrointestinal symptoms. Therefore, the drug used in combination with other drugs, alone less.