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目的讨论大剂量与小剂量秋水仙碱治疗急性痛风的临床治疗效果。方法以该院在2015年1月—2016年9月收治的40例急性痛风患者组作为研究对象,将其随机分为对照组和观察组,每组各20例,对照组使用大剂量秋水仙碱进行治疗,观察组使用小剂量秋水仙碱进行治疗。比较两组患者的治疗总有效率和不良反应发生率。结果观察组患者的治疗总有效率与对照组的治疗总有效率之间差异无统计学意义(P>0.05);观察组患者的不良反应发生率明显低于对照组,两组之间差异有统计学意义(P<0.05)。结论大剂量和小剂量秋水仙碱治疗急性痛风均有一定的疗效,但是利用小剂量进行治疗,能够有效的降低不良反应的发生率,值得在临床上推广使用。
Objective To discuss the clinical effects of high-dose and low-dose colchicine in the treatment of acute gout. Methods A total of 40 patients with acute gout treated in our hospital from January 2015 to September 2016 were selected and randomly divided into control group and observation group with 20 cases in each group. Alkali treatment, the observation group using a small dose of colchicine treatment. The total effective rate and incidence of adverse reactions in both groups were compared. Results There was no significant difference between the observation group and the control group (P> 0.05). The incidence of adverse reactions in the observation group was significantly lower than that of the control group Statistical significance (P <0.05). Conclusion Both high-dose and low-dose colchicine have certain curative effect in the treatment of acute gout. However, low-dose treatment can effectively reduce the incidence of adverse reactions and is worth popularizing in clinic.