目的　探讨内耳色素与爆震性听损伤的关系。方法　利用耳蜗铺片、石蜡切片、透射电镜及扫描电镜观察爆震前后白化豚鼠和杂色豚鼠耳蜗形态结构的变化 ,并对爆震前后白化豚鼠和杂色豚鼠听性脑干反应(ABR)反应阈进行测定。结果　白化豚鼠的耳蜗形态损伤和听功能损伤均较杂色豚鼠严重。结论　爆震后白化豚鼠耳蜗形态学损伤及ABR反应阈的改变均较杂色豚鼠明显。提示内耳血管纹色素颗粒与爆震性内耳损伤有关 ,机理可能为色素颗粒参与调节爆震后内淋巴液中钙离子浓度的平衡及参与清除爆震后耳蜗产生的氧自由基 Objective To investigate the relationship between pigmentation and detonation hearing loss in the inner ear. Methods The cochlear morphological changes of albino guinea pigs and variegated guinea pigs before and after detonation were observed with cochlear implants, paraffin sections, transmission electron microscopy and scanning electron microscopy. The changes of auditory brainstem response (ABR) in albino guinea pigs and variegated guinea pigs before and after detonation Threshold determination. Results Albino guinea pigs had more severe cochlear morphological and auditory impairment than those of variegated guinea pigs. Conclusion The morphological changes of the cochlea and the changes of ABR threshold in albino guinea pigs after detonation are more obvious than those in variegated guinea pigs. It is suggested that pigmentary pigment particles in the inner ear are related to the detonation of the inner ear. The mechanism may be that the pigment granules are involved in regulating the balance of calcium ion concentration in the endolymph after detonation and are involved in the clearance of the oxygen radicals generated by the cochlea after detonation