Two new cyclopeptides, leiocyclocin A (1), B (2), were isolated from the seeds of Goniothalamus leiocarpus. Their structures were elucidated by means of spectral and chemical methods. Two new cyclopeptides, leiocyclocin A (1), B (2), were isolated from the seeds of Goniothalamus leiocarpus. Their structures were elucidated by means of spectral and chemical methods.