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目的:探讨RIP3(受体相互作用蛋白-3)在淋巴瘤患者病理组织中是否表达及其亚细胞定位,并初步观察RIP3的表达是否与淋巴瘤病理恶性度相关。方法:(1)利用免疫组化技术检测48例淋巴瘤和非肿瘤侵润淋巴结病理组织中RIP3表达,并观察RIP3亚细胞定位。结果:(1)RIP3在淋巴瘤患者病理组织中均有表达,其亚细胞定位主要在细胞核,在细胞质中相对弱表达。(2)RIP3表达与淋巴瘤病理恶性度可能存在相关性。结论:RIP3在淋巴瘤患者病理组织中存在阳性表达,为研究RIP3是否与淋巴瘤的发病、临床表现和预后相关,提供了新的探索途径。
Objective: To investigate whether RIP3 (receptor interacting protein - 3) is expressed in the pathological tissues of patients with lymphoma and its subcellular location, and to observe whether RIP3 expression correlates with the pathological grade of lymphoma. Methods: (1) Immunohistochemical technique was used to detect the expression of RIP3 in 48 cases of lymphoma and non-tumor infiltrating lymph node, and to observe the subcellular localization of RIP3. Results: (1) RIP3 was expressed in the pathological tissues of patients with lymphoma. The subcellular localization of RIP3 was mainly in the nucleus and relatively weakly expressed in the cytoplasm. (2) There may be correlation between the expression of RIP3 and the pathological grade of lymphoma. Conclusion: RIP3 is positively expressed in the pathological tissues of patients with lymphoma, which provides a new way to explore whether RIP3 is associated with the onset, clinical manifestations and prognosis of lymphoma.