羊膜穿刺术是产前诊断的几种方法之一,其不足之处是本操作时间偏晚,当获得不正常结果时妊娠常常已接近孕20周,病人难于中断妊娠。1986年作者实验室已证实孕12～14周时获得的羊水细胞可用标准方法培养,得到高质量G 带制片(未发表材料)。1987年以来作者对不足15周孕妇采用羊膜穿刺的产前诊断法,本文叙述作者的经验及连续222例病人的随访情况。接受产前诊断的病人是由家庭和产科医生转到地区遗传/产科门诊的。由临床遗传学家和产科医 Amniocentesis is one of several methods of prenatal diagnosis, the downside is that this operation is too late, when the abnormal results get pregnant often close to 20 weeks of pregnancy, the patient is difficult to interrupt the pregnancy. In 1986, the authors laboratory has confirmed that amniotic fluid cells obtained from 12 to 14 weeks of pregnancy can be cultured by standard methods to obtain high-quality G-band preparations (unpublished material). The authors have used prenatal diagnosis of amniocentesis for pregnant women less than 15 weeks since 1987. This article describes the author’s experience and the follow-up of 222 consecutive patients. Patients receiving prenatal diagnosis are referred by family and obstetricians to a district genetic / obstetric clinic. By clinical geneticists and obstetricians