色胺(Tryptamine),化学名为3-(2-氨乙基)吲哚,是合成治疗脑动脉硬化的长春胺和脱水长春胺乙酯等生物碱的中间体,同时也是一种化学试剂。文献报道的合成方法较多,主要有下列四种:(1)γ-氯丁醛和苯肼缩合法,(2)3-氯丙基丙二酸乙酯和氯化重氮苯偶合法,(3)乙酰吲哚满基酮为原料的Wittig反应法,(4)以丙烯腈和丙二酸乙酯为原料的六步法,其反应式如下: Tryptamine, a chemical name of 3- (2-aminoethyl) indole, is an intermediate for the synthesis of alkaloids such as vincamine and vincamine in cerebral arteriosclerosis and is also a chemical reagent. There are many synthetic methods reported in the literature, mainly in the following four ways: (1) γ-chlorobutanal and phenylhydrazine condensation method, (2) 3-chloropropylmalonic acid ethyl ester and diazide chloride coupling method, (3) Acetylindolinone as the raw material Wittig reaction, (4) to acrylonitrile and ethyl malonate as the raw material six-step method, the reaction is as follows: