论文部分内容阅读
铁是一个可接受或提供电子转移的金属,能促进氧化还原反应,Fe~(2+)可催化自由基的变化,能诱发脂类化合物的氧化反应。脂类过氧化在动脉粥样硬化的致病机制中起着一个重要的作用,这是由于低密度脂蛋白中的多种不饱和氨基酸的脂质过氧化可促进动脉粥样硬化的形成。两项最新的研究表明:血清铁蛋白浓度与冠心病和颈动脉粥样硬化的危险因素有关。也有作者报告转铁蛋白的增加与冠心病的危险因素无关。
Iron is a metal that can accept or provide electron transfer and can promote redox reaction. Fe 2+ can catalyze the change of free radicals and induce the oxidation reaction of lipid compounds. Lipid peroxidation plays an important role in the pathogenesis of atherosclerosis because lipid peroxidation of various unsaturated amino acids in low-density lipoproteins promotes the development of atherosclerosis. Two recent studies have shown that serum ferritin levels are associated with risk factors for coronary heart disease and carotid atherosclerosis. There are also reports that an increase in transferrin has nothing to do with risk factors for coronary heart disease.