论文部分内容阅读
子痫前期是病理产科中常见的疾病,是导致孕产妇和围生儿死亡的主要原因,其具体病因目前尚未完全阐明,大多数学者认为主要与氧化应激导致的血管内皮细胞损伤,胎盘浅着床,免疫平衡的破坏等因素有关,其中内皮细胞损伤导致的内皮细胞生理功能失衡是其病因学研究的热点。CD40/CD40L是一对互补的肿瘤坏死因子和肿瘤坏子因子受体超家族跨膜糖蛋白,相互作用可以促进内皮细胞、平滑肌细胞表达和释放细胞因子、组织因子、金属蛋白酶、粘附分子,这些物质间接或直接的参与了炎症反应和免疫调节,导致内皮细胞损伤。因此,CD40/CD40L相互作用在炎症反应和免疫失调中亦起着关键作用,可能是子痫前期的病因之一,以CD40/CD40L为靶点为子痫前期的诊断和治疗提供了新的思路和方向。本文拟对CD40/CD40L信号系统与子痫前期的关系做一综述。
Pre-eclampsia is a common disease in obstetrics and gynecology, is the leading cause of death of pregnant women and perinatal children, the specific cause is not yet fully elucidated, most scholars believe that the main and oxidative stress-induced vascular endothelial cell injury, placental shallow Implantation, the destruction of immune balance and other factors, of which endothelial cell injury caused by imbalance of endothelial function is its etiology of hot spots. CD40 / CD40L is a pair of complementary tumor necrosis factor and tumor necrosis factor receptor superfamily transmembrane glycoprotein, the interaction can promote the expression of endothelial cells and smooth muscle cells and the release of cytokines, tissue factor, metalloproteinase, adhesion molecules, These substances indirectly or directly involved in the inflammatory response and immune regulation, leading to endothelial cell damage. Therefore, the CD40 / CD40L interaction also plays a key role in the inflammatory response and immune disorders and may be one of the causes of preeclampsia, providing a new idea for the diagnosis and treatment of preeclampsia with CD40 / CD40L as a target And direction. This article intends to review the relationship between CD40 / CD40L signaling system and preeclampsia.