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目的:分析以阿霉素等化疗药物经肝动脉灌注化疗并栓塞治疗中晚期原发性肝癌的疗效和毒性反应。方法:不能接受手术治疗的中晚期肝癌患者41例,采用阿霉素、顺铂以及5-氟脲嘧啶等化疗药物与碘化油联合经肝动脉栓塞灌注治疗。结果:41例共接受102次介入治疗。22例AFP明显下降或恢复正常。部分缓解21例,稳定16例,进展4例,总有效率51.2%。0.5、1、2а生存率分别为87.2%、58.1%、19.0%。不良反应主要为Ⅰ~Ⅲ度的骨髓抑制和Ⅰ~Ⅱ度的消化道反应。结论:以阿霉素为主的药物经肝动脉栓塞化疗治疗中、晚期肝癌,疗效好,毒副作用小。
Objective: To analyze the efficacy and toxicity of hepatic arterial infusion chemotherapy and embolization with adriamycin and other chemotherapy drugs for the treatment of advanced primary liver cancer. Methods: Forty-one patients with advanced hepatocellular carcinoma who could not undergo surgery were treated with hepatic artery embolization with doxorubicin, cisplatin and 5-fluorouracil and other chemotherapeutic drugs combined with iodized oil. Results: Forty-one patients received 102 interventions. 22 cases of AFP significantly decreased or returned to normal. Partial remission in 21 cases, stable in 16 cases, progress in 4 cases, total effective rate 51.2%. The survival rates of 0.5, 1, and 2 were 87.2%, 58.1%, and 19.0%, respectively. The adverse reactions were mainly myelosuppression of I-III degree and digestive tract reaction of I-II degree. Conclusion: The treatment of hepatocellular carcinoma with hepatic arterial embolization with doxorubicin-based drugs has good curative effect and little side effects.