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[目的]探讨高血压患者左心室肥厚及其功能改变的影响因素.[方法]选取2014年1月至2016年4月本院收治的100例高血压患者为研究对象,根据患者的动态动脉硬化指数(AASI)将其分为观察组(AASI>0.51,n=45)和对照组(AASI≤0.51,n=55).采用无创袖带式全自动血压测量仪监测两组患者24 h动态血压;采用西门子S2000彩色超声诊断仪测量两组患者左心室舒张末期内径(LVDd)、室间隔厚度(IVST) 、左心室后壁舒张末期厚度(LVPW)、室壁相对厚度(LVPWTD)、动态动脉硬化指数(AASI)、左心室质量指数(LVMI);比较两组患者24 h平均收缩压(24 hSBP)、24h平均舒张压(24 hDBP)、24 h动态脉压(24 hPP);比较两组患者空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等生化指标.[结果]观察组24 hSBP、24 hPP显著高于对照组,24 hDBP、24 hHR显著低于对照组,差异均具有统计学意义(均P<0.05).观察组与对照组在血清TG、TC、HDL-C水平、年龄、病程、AASI、LVMI方面比较,差异具有统计学意义(均P<0.05).将两组患者具有统计学差异的指标行多因素logistics回归分析,24 hSBP、24 hPP、AASI均为导致高血压患者左心室肥厚以及功能改变的独立危险因素(均P0.51,n=45) and control group (AASI=0.51,n=55).Non-invasive cuff blood pressure instrument was used for automatic monitoring of patients in two groups of 24 h ambulatory blood pressure;left ventricular end diastolic diameter (LVDd),interventricular septal thickness (IVST),left ventricular posterior wall end diastolic thickness (LVDd),relative wall thickness (LVPWTD),ambulatory arterial stiffness index (AASI),left ventricular mass index (LVMI) of the two groups were measured by SIEMENS S2000 color ultrasonic diagnostic instrument;24h mean systolic pressure (24hSBP),24h mean diastolic pressure (24hDBP) and 24h dynamic pulse pressure (24hPP) were compared between the two groups;fasting blood glucose (FPG),three acyl glycerol (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) and other biochemical indexes were compared between the two groups.[Results]24hSBP and 24hPP of the observation group were significantly higher than those of the control group,24hDBP and 24hHR were significantly lower than those of the control group,the difference was statistically significant (both P<0.05).The difference of serum TG,TC,HDL-C levels,age,course of disease,AASI and LVMI between the observation group and the control group was statistically significant (P<0.05).The index for the two groups of patients had statistical differences in the logistics regression analysis,24hSBP,24hPP and AASI were independent risk factors led to the change of hypertension patients with left ventricular hypertrophy and function (P<0.05).[Conclusion]24hSBP,24hPP and AASI are independent risk factors for left ventricular hypertrophy and functional changes in hypertensive patients.Active treatment is needed to control their blood pressure level and to improve their awareness of hypertension.