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目的观察中西药联合分期综合治疗痛风性关节炎的临床效果。方法将70例痛风性关节炎患者随机分为试验组和对照组,每组35例。对照组患者在初诊时采用秋水仙碱片和洛索洛芬钠片治疗,间隙期采用苯溴马隆片治疗;急性发作期给予秋水仙碱片、洛索洛芬钠以及苯溴马隆片联合治疗;试验组患者在对照组治疗的前提下,初诊和急性发作期采用清热利湿方药治疗,间隙期采用健脾利湿方药治疗。全部患者均进行为期24周的治疗。对比2组治疗前后VAS、PGA评分,关节炎急性发作次数和不良事件发生情况。结果治疗前2组VAS评分、PGA评分比较差异无统计学意义(P>0.05)。治疗后,2组VAS评分降低,PGA评分升高,且试验组优于对照组(P<0.05)。治疗期间对照组关节炎急性发作次数为(4.53±1.87)次高于试验组的(3.76±2.24)次,差异有统计学意义(P<0.05)。治疗期间,对照组患者出现转氨酶上升2例;试验组患者发生转氨酶上升1例。2组患者治疗期间肾功能、心电图、二便常规、血常规均未发生显著异常(P>0.05)。结论临床中在对痛风性关节炎患者进行治疗时,中西药联合分期综合治疗能让患者的急性发作次数显著减少,让关节疼痛程度有效减轻,而且安全可靠,具有临床推广价值。
Objective To observe the clinical effects of integrated traditional Chinese and western medicine in the treatment of gouty arthritis. Methods Seventy patients with gouty arthritis were randomly divided into experimental group and control group, 35 cases in each group. Patients in the control group were treated with colchicine tablets and loxoprofen sodium tablets in the first visit, while benzbromarone tablets were used in the interstitial period. Colchicine tablets, loxoprofen sodium and benzbromarone tablets Combined treatment; experimental group of patients in the control group under the premise of the first visit and acute exacerbation with Qingre dampness prescription treatment, interstitial use of spleen and dampness prescriptions. All patients were treated for 24 weeks. The VAS, PGA scores, the number of acute exacerbations and incidence of adverse events in two groups were compared before and after treatment. Results There was no significant difference in VAS score and PGA score between the two groups before treatment (P> 0.05). After treatment, VAS score decreased, PGA score increased, and the experimental group was better than the control group (P <0.05). The number of acute exacerbations of arthritis in the control group during the treatment period was (4.53 ± 1.87) times higher than that in the experimental group (3.76 ± 2.24), the difference was statistically significant (P <0.05). During the treatment period, patients in the control group showed two cases of elevated aminotransferase; one case of aminotransferase increased in the test group. There were no significant abnormalities in renal function, electrocardiogram, second routine and blood routine in the two groups during treatment (P> 0.05). Conclusion In clinical treatment of patients with gouty arthritis, the combination of traditional Chinese and western medicine can significantly reduce the number of patients with acute seizures, reduce the degree of joint pain, and is safe and reliable, with clinical promotion value.