本文报告我院1971年～1992年收治的系统性红斑狼疮（SLE）18例。认为对长期不明原因发热，特别是间隙高热伴皮肤损害者，应尽早做血、尿常规，心电图、胸部摄片检查。血补体及C_3检查对肾脏损害有指导性诊断价值，补体测定可做为SLE肾脏病变活动和指导估计预后的指标。狼疮细胞和抗核抗体检查受肾上腺皮质激素类药物影响，需将激素减量或停药，反复多次检查，方可提高阳性率，早期明确诊断。 This article reports 18 cases of systemic lupus erythematosus (SLE) admitted to our hospital from 1971 to 1992. That long-term unexplained fever, especially high fever with skin damage, should do blood, urine, ECG, chest radiography. Blood complement and C_3 examination of the damage of the kidney has a guiding diagnostic value, complement determination can be used as an indicator of SLE activity and guide the prognosis of renal disease. Lupus cells and anti-nuclear antibodies by corticosteroids, hormones need to be reduced or withdrawal, repeated multiple checks before being able to increase the positive rate of early diagnosis.