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目的 对宫颈上皮内瘤变 (CIN)筛查方法即宫颈涂片自动检测系统 (papnetcytologycomputertechnology ,CCT)和新柏氏程控超薄细胞检测系统 (thinpreppaptest,TPT)两种细胞学检查方法进行综合评价。方法 对因细胞学检查异常而行阴道镜下多点活组织检查 (活检 )及病理检查的 374例患者的临床资料进行回顾性分析。结果 细胞学检查诊断为炎症者 9 1% ,低度鳞状上皮内瘤变(LSIL) 4 3 3% ,高度鳞状上皮内瘤变 (HSIL) 2 0 3% ,可疑癌 1 9% ;经阴道镜下多点活检及病理检查 ,诊断为炎症者增加到 5 3 5 % ,CINⅠ减少到 17 9% ,CINⅡ、CINⅢ、原位癌占 2 5 4 % ,可疑早期浸润癌和浸润癌增加到 3 2 %。 2 5 4 %的细胞学不能明确诊断意义的不典型鳞状上皮病变中 ,5 2 6 % (5 0 /95 )为炎症或未见异常 ,4 7 4 % (45 /95 )为CINⅠ以上的病变。 374例患者中 ,行CCT检查者 188例 ,TPT检查者 186例 ,两种细胞学检查结果分别与阴道镜检查结果相比 ,TPT的符合率显著高于CCT(P<0 0 1)。细胞学检查诊断为LSIL及以下病变的符合率 (79 7% )显著高于诊断为HSIL以及癌变者的符合率 (2 0 3% ) ,两者比较 ,差异有显著性 (P <0 0 1) ,而两种细胞学检查方法间无差别。人乳头状瘤病毒 (HPV)感染的发生率为 34 0 % ,阴道镜检查的
Objective To evaluate the CIN screening methods, that is, the two methods of cytology, papnet cytology (CCT) and thinprepaptest (TPT). Methods A retrospective analysis was performed on the clinical data of 374 patients undergoing colposcopy biopsy and biopsy due to cytology abnormalities. Results Cytological examination revealed 91% of the patients with inflammation, 43.3% of the patients with low grade squamous intraepithelial neoplasia (LSIL), 203% of the patients with high grade squamous intraepithelial neoplasia (HSIL) and 19% of the suspicious cancers Colposcopy and biopsy and pathological examination, the diagnosis of inflammation increased to 535%, CIN I reduced to 17 9%, CIN Ⅱ, CIN Ⅲ, carcinoma in situ accounted for 25.4%, suspicious early invasive cancer and invasive cancer increased to 3 2%. Among 52.4% of atypical squamous cell lesions whose cytology can not be definitively diagnosed, 52.6% (50/95) had inflammation or no abnormality, and 47.4% (45/95) had CINI or higher Lesions. Of the 374 patients, 188 were CCT and 186 were TPT, respectively. Comparing the results of two cytology tests with those of colposcopy, the coincidence rate of TPT was significantly higher than that of CCT (P <0.01). The coincidence rate (79 7%) of cytological examination diagnosed as LSIL and below was significantly higher than that of HSIL diagnosed as cancerous (20.3%), the difference was significant (P 0 01 ), While there was no difference between the two cytological methods. The incidence of human papillomavirus (HPV) infection was 34%, colposcopy