美国卫生部已经宣布在2000年前要成为不吸烟的国家。为了实现这一目标,所有单位与工作场所已成为大规模戒烟的环境。为了评价吸烟对公共卫生的影响,判定这些现场环境的吸烟状况是必要的。虽然目前评价吸烟状况有几项生化指标,但这些指标的应用在费用、准确度以及可靠性方面有差异,而且在现场环境进行采样时很不方便。测定在体内维持时间较长的尼古丁代谢物如可铁宁似乎比测定香烟的吸收成分更适用于确定吸烟状况。可铁宁这个指标似乎比 The U.S. Department of Health has announced that it will become a non-smoking country by 2000. In order to achieve this goal, all units and workplaces have become environments for mass smoking cessation. In order to assess the impact of smoking on public health, it is necessary to determine the smoking status in these site settings. Although there are several biochemical indicators for assessing current smoking status, the use of these indicators varies in cost, accuracy and reliability, and is inconvenient when sampling in the field environment. Determining nicotine metabolites such as cotinine, which lasts longer in the body, appears to be more suitable for determining smoking status than measuring the absorption profile of cigarettes. Kettering this indicator seems to be more than