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目的 为研究我国汉族与蒙古族维生素D受体(VDR)基因多态性分布与骨质疏松的关系。方法 采用聚合酶链反应(PCR)限制性片段长度多态性技术,对179例健康汉族人及105例蒙古族健康人进行VDR基因检测。结果 中国蒙古族105例,bb型54例(51.42％),Bb型45例(42.85％),BB型6例(5.71％);汉族179例,bb型162例(90.50％),Bb型17例(9.50％),未见BB型。结论 中国蒙古族VDR基因多态性分布与中国汉族相比差异有显著性意义(P<0.005)。
Objective To study the relationship between distribution of vitamin D receptor (VDR) gene polymorphism and osteoporosis in Han and Mongolians in China. Methods Polymerase chain reaction (PCR) restriction fragment length polymorphism was used to detect VDR gene in 179 healthy Han nationality and 105 Mongolian healthy people. Results There were 105 cases of Mongolian nationality in China, including 54 cases (51.42%) of bb type, 45 cases (42.85%) of Bb type and 6 cases (5.71%) of BB type in Han nationality, 162 cases (90.50%) of bb type, Cases (9.50%), no BB type. Conclusion The distribution of VDR gene polymorphism in Mongolian in China is significantly different from that in Han Chinese (P <0.005).