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本文报告一例病程长达6个月的肠道传播的非甲非乙型肝炎[Enterically Transmitted non-A non-B Hepatitis,简称HNANB(E)]病人肝穿活检标本的光镜和电镜观察结果。光镜下肝细胞大小一致,多呈疏松样变。肝小叶界板完整,小叶内有点状坏死灶。门管区有轻-中度炎性反应。电镜下肝细胞的细胞器变性且减少,多分布在核周和细胞膜下。肝细胞间隙增宽,微绒毛增多。Disse间隙内储脂细胞和胶原纤维增生。肝窦内Kupffer细胞肥大,少量致敏的淋巴细胞穿越窦壁与肝细胞密切接触。本例符合慢性迁延性肝炎(CPH)的病理和超微病理的改变。
This article reports the results of light and electron microscopy of a transurethral non-A non-B hepatitis B (HNANB (E)) patient enrolled in a biopsy of the liver that lasted up to 6 months. Light microscope, the same size of hepatocytes, mostly loose like. Hepatic lobule sector intact, lobular necrosis within the spot. Portal area with mild - moderate inflammatory response. Electron microscope, hepatocytes organelles degeneration and decrease, and more distributed in the perinuclear and sub-membrane. Liver cell gap widened, microvilli increased. Disse gap in the fat cells and collagen fibers hyperplasia. Kupffer cells in the liver sinus hypertrophy, a small amount of sensitized lymphocytes through the sinus wall and liver cells in close contact. This case is consistent with the pathological and ultrastructural changes of chronic persistent hepatitis (CPH).