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目的:探讨服用竹叶提取物对大强耐力训练大鼠组织自由基代谢的影响。方法:24只SD大鼠随机分为安静组、运动组和运动加药组,每组8只。运动组进行6周大强度跑台训练,运动加药组除大强度跑台训练外,按300 mg.kg-1.d-1的用量灌服竹叶提取物水分散液;安静组和运动组灌服同体积的蒸馏水。6周后,测量各实验组大鼠心肌、肝、肾组织的超氧化物歧化酶(SOD),总抗氧化能力(T-AOC),过氧化氢酶(CAT),丙二醛(MDA),还原性谷胱甘肽(GSH)和谷胱甘肽过氧化物酶(GSH-Px)等生化指标;测量运动组和运动加药组的运动能力。结果:力竭运动引起大鼠心、肝、肾组织SOD,CAT,T-AOC,GSH-Px和GSH等生化指标显著下降,MDA含量显著上升,而服用竹叶提取物可以抑制各种抗氧化酶活性的下降趋势,降低组织MDA含量,使大鼠力竭运动时间提高28.87%。结论:补充竹叶提取物可以促进力竭运动大鼠的自由基代谢,提高其运动能力,适于作为抗运动疲劳补剂的原料。
Objective: To investigate the effects of taking bamboo leaves extract on the metabolism of free radicals in the tissues of rats with strong endurance training. Methods: Twenty-four SD rats were randomly divided into tranquilizer group, exercise group and exercise plus drug group, with 8 rats in each group. Exercise group for 6 weeks intensity treadmill training, exercise plus medicine group in addition to intensive treadmill training, according to 300 mg.kg-1.d-1 dosage of bamboo extract aqueous dispersion; Quiet group and exercise Group fed the same volume of distilled water. Six weeks later, the activities of superoxide dismutase (SOD), total antioxidant capacity (T-AOC), catalase (CAT), malondialdehyde (MDA) , Reducing glutathione (GSH) and glutathione peroxidase (GSH-Px) and other biochemical indicators; exercise group and exercise dosing group exercise capacity. Results: The biochemical indexes such as SOD, CAT, T-AOC, GSH-Px and GSH in heart, liver and kidney of rats after exhaustive exercise were significantly decreased and MDA content was significantly increased. However, taking bamboo leaves extract could inhibit various antioxidants Decreasing trend of enzyme activity, reducing tissue MDA content, so that rats spent 28.87% of exercise time. Conclusion: Supplementing the extract of bamboo leaves can promote the metabolism of free radicals in rats after exhaustive exercise, improve their exercise capacity, and be suitable as a raw material for anti-exercise fatigue supplements.