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对68例胃溃疡(GU)患者治疗前后的胃粘膜电位差(PD)和病理组织学进行了对照研究。GU治疗前后PD均显著低于正常对照组(P<0.01),病理组织学检查示除溃疡外,均同时伴存慢性胃炎,且PD与炎性细胞浸润的组织学积分呈显著负相关。GU经雷尼替丁治愈者,胃炎无明显改善,1年复发率为66.7%;而经De-Nol治愈者胃炎显著减轻(P<0.01),1年复发率为33.3%,显著低于雷尼替丁组(P<0.05)。结果提示:慢性胃炎可能是GU患者胃粘膜屏障功能损害、溃疡发病和易复发的一个重要原因;对合并慢性胃炎的GU患者,选用De-Nol可能更为理想。
68 patients with gastric ulcer (GU) before and after treatment of gastric mucosal potential difference (PD) and histopathology were compared. PD before and after treatment was significantly lower than that of the normal control group (P <0.01). Pathological examination showed chronic gastritis accompanied with ulceration, and there was a significant negative correlation between PD and histological score of inflammatory cell infiltration. Gastritis was not significantly improved in patients with GU after ranitidine treatment, with a one-year relapse rate of 66.7%. Gastritis was significantly relieved (P <0.01) after one-year treatment with De-Nol, with a one-year relapse rate of 33.3%, significantly lower than that of Thunder Nilotin group (P <0.05). The results suggest that chronic gastritis may be an important cause of gastric mucosal barrier dysfunction, ulcer incidence and relapse in GU patients. De-Nol may be more ideal for GU patients with chronic gastritis.