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目的评价泉州市结核分枝杆菌的耐药状况。方法连续收集2001—2005年本所门诊及住院肺结核病例的菌株做药敏试验。结果2001—2005年耐药率分别为26.2%、29.1%、27.2%、30.9%和25.6%;初治耐药率分别为14.9%、17.9%、12.8%、9.3%和9.5%;复治耐药率分别为67.6%、69.7%、57.4%、61.9%和68.3%。耐单药率以INH、RFP、SM3药较高。耐多种药率以SH、SR、HR、SHR、HRE、SHRE较高。结论泉州市结核病的耐药率较高,情况较严重,控制耐药的关键是早发现、早治疗,采用DOTS策略彻底治愈传染性肺结核,并做好耐药监测评价工作。
Objective To evaluate the drug resistance of Mycobacterium tuberculosis in Quanzhou. Methods The strains susceptible to the outpatient and in-hospital pulmonary tuberculosis cases from 2001 to 2005 were collected continuously. Results The rates of drug resistance in 2001-2005 were 26.2%, 29.1%, 27.2%, 30.9% and 25.6%, respectively. The initial drug resistance rates were 14.9%, 17.9%, 12.8%, 9.3% and 9.5% Drug rates were 67.6%, 69.7%, 57.4%, 61.9% and 68.3%, respectively. Resistance to monotherapy with INH, RFP, SM3 drug higher. Resistance to multiple drug rates to SH, SR, HR, SHR, HRE, SHRE higher. Conclusion The drug resistance rate of TB in Quanzhou is high and the situation is more serious. The key to control drug resistance is early detection and early treatment. DOTS strategy is used to completely cure infectious tuberculosis and make monitoring and evaluation of drug resistance.