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受体的特征对甾类激素在各组织内的效应已了解多年,但其受体仅约20年前才由Jensen首次报道.迄今所有甾类激素的受体均已被描述.Jensen等提出的甾类受体作用的两室模式(two-compartment model)最受公认:甾类先弥散入细胞并与胞浆中高度特异的受体分子相结合;然后,甾类-受体复合物发生构象改变(激活或转化)并进入核内,与基因组上特异的接受顺序连接.核受体主动中介该激素特异的细胞效应,而胞浆受体则代表具有与核相互作用潜能的附加受体.最近有人对比二室模式表示异议,提出雌激素受体(ER)可能局限于胞核.但这些观察有待证实,在目前,区别胞浆和核受体仍
The characteristics of receptors have been known for many years for the effect of steroid hormones in various tissues, but their receptors were first reported by Jensen only about 20 years ago. So far all receptors for steroid hormones have been described. The two-compartment model of the steroid receptor is most commonly recognized: steroids diffuse into cells and bind to highly specific receptor molecules in the cytoplasm; and then the steroid-receptor complex conformation Change (activate or transform) and enter the nucleus to connect with the specific order of acceptance on the genome.Nucleoreceptors actively mediate this hormone-specific cellular effect, whereas cytoplasmic receptors represent additional receptors that have the potential to interact with nuclei. Recently, some people expressed opposition to the two-compartment model, suggesting that the estrogen receptor (ER) may be confined to the nucleus, but these observations remain to be confirmed, at present, the difference between cytoplasmic and nuclear receptors