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以多巴胺D2 受体配体Cl ABZM为前体 ,合成了末端带有巯基的单齿化合物 ,光谱数据与结构相符 .用配体交换法与 3 硫杂 1,5 戊二硫醇共同配位合成了“3+ 1”型混配螯合物 ,对影响标记率的诸多因素如 pH值、温度、配体用量及反应时间等进行了优化 ,得到最佳标记条件 ,标记率大于 85%
Using dopamine D2 receptor ligand Cl ABZM as the precursor, a monodentate compound with terminal sulfhydryl group was synthesized and the spectral data was consistent with the structure. The ligand exchange method co-coordinated with 3-thio-1,5-pentanethiol The “3 + 1” chelate compound was optimized. The factors affecting the labeling efficiency were optimized, such as pH value, temperature, ligand dosage and reaction time. The optimal labeling conditions were obtained. The labeling rate was more than 85%