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目的研究表皮生长因子(EG F)及其受体(EG FR)在肝细胞癌(H C C)组织中的表达及其与临床病理的关系。方法应用免疫组化S蛳P方法检测55例H C C患者癌组织及癌旁肝组织中EG F和EG FR的表达情况。结果在55例H C C患者癌组织及其癌旁组织中,EG F阳性表达率分别为54.55%(30/55)和76.36%(42/55),两者差异有显著性(P<0.05);EG FR阳性表达率分别为58.18%(32/55)和36.36%(20/55),两者差异有显著性(P<0.05)。EG FR在H C C组织中的阳性表达率与临床分期、门静脉癌栓、肝外转移、术后复发等显著相关,而与肿瘤直径、肿瘤数目、血清AFP水平以及分化程度无明显关系。EG F阳性表达率与各临床病理参数无关。结论EG F可能与H C C的发生、发展无关;而EG FR与H C C的发生、发展有关,可作为预测H C C复发、转移的参考指标。
Objective To investigate the expression of epidermal growth factor (EGF) and its receptor (EG FR) in hepatocellular carcinoma (HCC) tissues and its relationship with clinicopathology. Methods Immunohistochemical S 蛳 P method was used to detect the expression of EG F and EG FR in 55 cases of HCC patients with cancer tissues and adjacent liver tissues. Results The positive expression rates of EG F in 54 cases of HCC patients and their adjacent tissues were 54.55% (30/55) and 76.36% (42/55), respectively. There was a significant difference between the two groups (P <0.05). The positive rates of EG FR were 58.18% (32/55) and 36.36% (20/55), respectively, with significant difference (P <0.05). The positive expression rate of EG FR in HCC tissues was significantly correlated with clinical stage, portal vein tumor thrombus, extrahepatic metastasis and postoperative recurrence, but not with tumor diameter, tumor number, serum AFP level and differentiation degree. The positive rate of EG F was not related to the clinicopathological parameters. Conclusion EG F may not be related to the occurrence and development of H C C, while EG FR is related to the occurrence and development of H C C and may serve as a reference index for predicting the recurrence and metastasis of H C C.