表皮的组织结构和功能有赖于角质形成细胞增殖分化平衡,失衡是许多皮肤病如银屑病等的特征。研究表明成纤维细胞源性多种因子可调节角质形成细胞增殖分化平衡,银屑病成纤维细胞表型和功能改变参与银屑病的发病机制[1,2]。由一氧化氮合成酶(NOS)介导合成的一氧化氮(NO)参与各种 The tissue structure and function of the epidermis depend on the balance of proliferation and differentiation of keratinocytes, and the imbalance is a feature of many skin diseases such as psoriasis. Studies have shown that fibroblast-derived factors can regulate the balance of proliferation and differentiation of keratinocytes, and the psoriatic fibroblast phenotype and function changes are involved in the pathogenesis of psoriasis [1, 2]. Nitric oxide (NO) synthesis mediated by nitric oxide synthase (NOS) participates in various