1981年12月,英国德文有2例4月龄女婴,在服用同一批三价脊髓灰质炎疫苗后14～26天发生了麻痹性脊髓灰质炎,两年后仍留有后遗症。由于两例间相距13公里,且均居住当地,互不来往,没有与其他接种者有过密切接触史,故怀疑可能由疫苗引起,对此进行了广泛的流行病学及病毒学调查。病例从临床上不能与急性脊髓炎相区 In December 1981, there were 2 four-month-old female infants in Devon, England, who developed paralytic poliomyelitis 14 to 26 days after taking the same trivalent polio vaccine and two years after that left sequelae. The epidemiological and virological investigations were extensively conducted as the vaccine was suspected because of a distance of 13 kilometers between the two cases, both residing locally and not traveling to each other and having no history of close contact with other vaccinates. Cases can not clinically acute meningitis phase area