血管内皮细胞(vascular endothelial cell,VEC)是铺陈于血管壁内侧的一种多功能的细胞,对血栓与止血、炎症与免疫和血管新生、物质转运等多种生理、病理过程具有重要的调节功能。当凋亡触发因子作用于VEC时,细胞内出现多种调控基因表达改变、蛋白酶活化等一系列的变化,并出现胞膜泡状突起,染色质浓缩,细胞核裂解以及膜分子结构和功能等的改变,从而参与血栓形成、动脉粥样硬化、高血压等多种病理过程。 Vascular endothelial cell (VEC) is a kind of multi-functional cell which is laid on the inside of the blood vessel wall and plays an important regulatory role in many physiological and pathological processes such as thrombosis, hemostasis, inflammation and immunity, angiogenesis and substance transport . When the apoptosis triggering factor acts on VEC, a series of changes occur in the cell such as the change of the expression of many regulatory genes and the activation of protease, and the appearance of the cell vacuolar process, the chromatin condensation, the nuclear lysis and the molecular structure and function of the membrane Change, and thus involved in thrombosis, atherosclerosis, hypertension and other pathological processes.