目的 :探讨肠道平滑肌钙拮抗剂匹维溴铵对肠易激综合征 (IBS)的临床疗效。方法 :对2 80例确诊 IBS病人进行多中心、开放性研究 ,病人口服匹维溴铵 5 0 mg,每天 3次 ,疗程 4周。结果 :匹维溴铵对腹痛、腹泻、便秘症状缓解率分别是 72 %、 66%和 68% ,有效率分别是 92 %、 92 %和 85 % ,其他症状缓解率在 76%～ 96%之间 ,轻度不良反应仅 3.2 %。结论 :匹维溴铵是治疗 IBS安全有效的药物。 Objective: To investigate the clinical effect of piastatin, a calcium channel antagonist of intestinal smooth muscle, on irritable bowel syndrome (IBS). Methods: A multicenter, open-label study of 280 patients with definite IBS was conducted. The patients were treated with 50 mg of pinaverium bromide orally three times daily for 4 weeks. Results: The response rates of pinaverium bromide to abdominal pain, diarrhea and constipation were 72%, 66% and 68% respectively, and the effective rates were 92%, 92% and 85% respectively; the rates of other symptoms were between 76% and 96% Between, mild adverse reactions only 3.2%. Conclusions: Pivivirin is a safe and effective drug for the treatment of IBS.