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目的观察自研中成药脂肝宁口服液(ZGN)(含黄芪、白术、茵陈、金钱草等)对脂肪肝的临床疗效.方法选择脾虚湿困、肝胆湿热型脂肪肝患者148例,随机分为两组.观察组98例口服ZGN(20mL,2次/d),50例服用东宝肝泰(3片,3次/d)为对照.观察2组患者服药6wk后临床症状、血脂和肝脏影像学变化.结果观察组显效率为663%,总有效率为908%,对临床症状有较高的缓解率(833%~944%),可使血清总胆固醇、三酰甘油、低密度脂蛋白明显下降(P<001),使肝脏的影像学改变减轻或消失,脂肪肝消除率为398%.各疗效指标均优于东宝肝泰组.结论ZGN对脂肪肝及其伴随的高脂血症具有显著可靠的治疗作用.
Objective To observe the clinical effect of ZGN (including Astragalus, Atractylodes, capillaris, Champignon, etc.) on fatty liver. Methods 148 cases of spleen wet sleepy, liver and gallbladder fatty liver disease were randomly divided into two groups. In the observation group, 98 cases were given oral ZGN (20mL, twice daily) and 50 patients were given Dongbaogantai (3 tablets, 3 times daily) as control. Two groups of patients were observed after 6wk clinical symptoms, blood lipid and liver imaging changes. Results The observation group showed a markedly effective rate of 663% and a total effective rate of 908%, and had a high response rate (833% ~ 944%) to clinical symptoms. The total cholesterol, triglyceride , Low-density lipoprotein (P <001) decreased significantly, which reduced or eliminated the imaging changes of the liver. The rate of fatty liver elimination was 398%. The efficacy indicators are better than Dongbao liver group. Conclusion ZGN has a significant and reliable therapeutic effect on fatty liver and its accompanying hyperlipidemia.