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目的探讨多囊卵巢综合征应用吡格列酮与克罗米芬治疗的临床效果。方法 96例多囊卵巢综合征患者,按随机数字表法分为对照组和观察组,各48例。对照组给予克罗米芬口服治疗,观察组在克罗米芬治疗前3个月给予吡格列酮治疗。观察两组治疗效果。结果治疗后观察组总有效率95.83%明显高于对照组83.33%,差异有统计学意义(P<0.05);空腹胰岛素(FINS)、睾酮(T)、促黄体生成素(LH)、促卵泡生成素(FSH)明显低于对照组,差异有统计学意义(P<0.05)。结论吡格列酮联合克罗米芬治疗多囊卵巢综合征,可有效降低体内激素水平,促进排卵,效果显著,值得临床推广应用。
Objective To investigate the clinical effects of pioglitazone and clomiphene in patients with polycystic ovary syndrome. Methods 96 cases of PCOS patients were divided into control group and observation group according to random number table method, each 48 cases. The control group was given clomiphene citrate orally and the observation group was given pioglitazone 3 months before clomiphene citrate treatment. Observation of two groups treatment effect. Results After treatment, the total effective rate in observation group was 95.83%, which was significantly higher than that in control group (83.33%, P <0.05). The levels of FINS, The level of FSH was significantly lower than that of the control group (P <0.05). Conclusion Pioglitazone combined with clomiphene in the treatment of polycystic ovary syndrome can effectively reduce the body hormone levels and promote ovulation, the effect is significant, worthy of clinical application.