本文研究了利用不同病毒联合治疗中、晚期荷Ｓ_（１８０）小鼠，进行了不同病毒联合治疗的比较，同时对治疗机理进行了初步的探讨。结果表明：两种不同芽生病毒间隔治疗中晚期Ｓ_（１８０）小鼠，发现两次病毒的治疗间隔以５～７天为佳，其治愈率在８９％～１００％；进一步研究采用裂解病毒与芽生病毒间隔治疗中、晚期Ｓ_（１８０）小鼠，也能得到一定的疗效。 This article studies the use of different viruses in combination with the treatment of middle and late S180 mice and conducts a comparison of different combinations of viruses. At the same time, a preliminary discussion of the therapeutic mechanism has been conducted. The results showed that two different budding viruses were used to treat mid-to-late S_(180) mice, and it was found that the interval between two viral treatments was 5 to 7 days. The cure rate was 89% to 100%; further studies using split virus and Sputum virus treatment of intermediate and late S_(180) mice can also obtain certain efficacy.