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目的探讨手术切除膀胱联合膀胱灌注治疗膀胱肿瘤的临床效果。方法对我院收治的80例膀胱肿瘤患者,根据患者肿瘤分级、临床分期及患者病情分别采用膀胱部分切除术、经尿道膀胱肿瘤电切术、膀胱肿瘤切除术治疗,术后1～2周行吡柔比星膀胱灌注治疗,分析治疗效果及不良反应发生情况。结果全部患者均顺利完成灌注治疗,术中及术后未见明显并发症出现。本组15例于灌注后出现膀胱刺激症状,灌注后短暂出现尿频、尿急、尿痛等症,2～3 d后消失。随访1～3年中,8例患者膀胱镜检见复发行二次手术治疗,复发率为10%。结论在手术治疗后采用膀胱灌注治疗膀胱肿瘤,易被患者接受,预防复发效果好,不良反应少,尤其对多病灶复发的浅表膀胱癌有较好的治疗效果,值得临床推广应用。
Objective To investigate the clinical effects of surgical resection of bladder combined with intravesical instillation of bladder tumor. Methods Eighty patients with bladder cancer admitted to our hospital were treated with partial resection of the bladder, transurethral resection of the bladder tumor and resection of the bladder tumor according to the tumor grade, clinical stage and patient’s condition. The patients were treated 1 to 2 weeks after operation Pirarubicin bladder irrigation treatment, analysis of the treatment effect and adverse reactions. Results All patients were successfully completed perfusion therapy, intraoperative and postoperative no significant complications occurred. The group of 15 cases of bladder irritation after perfusion symptoms, transient urination appeared frequent urination, urgency, dysuria embolism, 2 ~ 3 d disappear. During 1 to 3 years of follow-up, cystoscopy was found in 8 patients with recurrent secondary surgery, with a recurrence rate of 10%. Conclusions Bladder instillation after surgical treatment of bladder tumor, easily accepted by patients, prevention of recurrence is good, less adverse reactions, especially for multi-lesion recurrence of superficial bladder cancer has a better therapeutic effect, worthy of clinical application.