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一、N,N′-双酰肼类化合物的一般制法系将酸制成酯,酯与水合肼作用生成酰肼,酰肼与酰氯于无水吡啶或无水乙腈中反应,即可制得。本文合成酰肼化合物一个,N,N′-双酰肼类化合物共六个,其中三个化合物经药理试验结果,无抗结核作用。二、多酰肼类化合物系采用酯与水合肼作用而得,其氨硫脲的衍生物可采用酰氯与氨硫脲反应而得。本文合成多酰肼及其氨硫脲类衍生物共六个(两个系已知的),其中四个化合物经药理试验结果,无抗结核作用。
First, N, N’-bis-hydrazide compounds of the general system Department of acid ester, esters and hydrazine hydrate generated hydrazide, hydrazide and acid chloride in anhydrous pyridine or anhydrous acetonitrile, the system can be Got it. In this paper, a synthetic hydrazide compound, N, N’-bis-hydrazide a total of six compounds, of which three compounds by the pharmacological test results, no anti-TB effect. Second, polyhydrazide compounds derived from the role of esters and hydrazine hydrate derived derivatives of thiourea can be used chloride and thiourea reaction derived. The synthesis of polyhydrazide and its ammonia thiourea derivatives a total of six (two known), of which four compounds by the pharmacological test results, no anti-TB effect.