抗体的特异性取决于抗体分子可变区的氨基酸顺序,这种特异性表现在几个决定簇或独特位(idiotope),这些决定簇或独特位统称为独特型。第一抗体的产生可被第二抗体即抗独特型抗体调节。抗独特型抗体也可用于分析免疫反应的异质性,研究独特位的交叉反应。作者通过实验观察了抗独特型抗体的产生、特性及鼠和人抗黑麦IIgE抗体独特位的交叉反应。 The specificity of an antibody depends on the amino acid sequence of the variable region of the antibody molecule. This specificity is expressed in several determinants or idiotopes, which are collectively referred to as idiotypes. The production of the first antibody can be modulated by the second antibody, anti-idiotypic antibody. Anti-idiotypic antibodies can also be used to analyze the heterogeneity of immune responses and to study the cross-reactivity of unique bits. The authors experimentally observed the generation of anti-idiotypic antibodies and their cross-reactivity with the unique epitopes of murine and human anti-rye IIgE antibodies.