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目的:探讨白细胞介素-1受体拮抗剂(interleukin-1 receptor antagonist gene IL-1ra)基因多态性与胃癌易感性的关系。方法:应用聚合酶链式反应(PCR)技术和酶联免疫吸附试验(ELISA)对济南地区65例胃癌患者和71例健康对照IL-1ra基因多态性和幽门螺杆菌(helicobacter pylori Hp)进行分析。结果:与对照组相比,胃癌患者IL-1ra基因多态性差异无统计学意义(P>0.05)。在淋巴结转移、Hp阳性胃癌组与无淋巴结转移和Hp阴性胃癌组,IL-1ra基因多态性差异无统计学意义(P>0.05)。IL-1ra基因多态性与不同分化程度之间的胃癌患者无关。结论:济南地区胃癌的易感性与IL-1ra基因多态性无关。
Objective: To investigate the relationship between interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and gastric cancer susceptibility. Methods: Polymorphisms of IL-1ra gene and helicobacter pylori Hp in 65 gastric cancer patients and 71 healthy controls in Jinan area were detected by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) analysis. Results: Compared with the control group, there was no significant difference in IL-1ra gene polymorphism between gastric cancer patients (P> 0.05). There was no significant difference in IL-1ra gene polymorphism between lymph node metastasis, Hp positive gastric cancer group and non-lymph node metastasis and Hp negative gastric cancer group (P> 0.05). IL-1ra gene polymorphism with different degrees of differentiation between gastric cancer patients has nothing to do. Conclusion: The susceptibility of gastric cancer in Jinan has nothing to do with IL-1ra gene polymorphism.