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随着介入诊疗及影像医学的快速发展,造影技术在临床已得到广泛应用。造影剂诱发的肾衰竭是目前医院内获得性急性肾衰竭的第三位原因,并且发病率和病死率逐年增加。造影剂肾病(CIN)的发病机制是肾髓质缺血,另外,细胞凋亡、氧自由基损害、免疫因素、肾小管阻塞等也有重要作用。在高血压、动脉粥样硬化等人群中,由于内皮细胞功能损害,更易造成CIN。现就目前研究较热的水化治疗、他汀类药物预防治疗等方法进行分析。
With the rapid development of interventional therapy and imaging medicine, angiography has been widely used clinically. Contrast-induced renal failure is the third leading cause of acquired acute renal failure in the hospital and the incidence and mortality are increasing year by year. Contrast-induced nephropathy (CIN) is the pathogenesis of renal medulla ischemia, in addition, apoptosis, oxygen free radical damage, immune factors, tubule obstruction also has an important role. In high blood pressure, atherosclerosis and other populations, due to endothelial dysfunction, more likely to cause CIN. Now on the study of hot hydration therapy, statins and other preventive treatment methods for analysis.